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SIGNOR signaling in Duaer

In Duaer: Causal signaling relations from SIGNOR: who activates, inhibits, or phosphorylates a protein, with mechanism, modified residue, PubMed evidence, and score. One successful search uses 1 credit.

What you get

Duaer SIGNOR signaling returns curated causal relations (regulator → effect → target) for a protein from SIGNOR. Duaer resolves a gene symbol to its reviewed UniProt accession first, and orders rows by SIGNOR score.

Pick Duaer Data → SIGNOR signaling in the node creator, or open the data market. Related: interactions, pathways, omnipath.

When to use it

Explain a pathway step: which kinase phosphorylates a protein, and at which residue.
List upstream regulators and downstream targets of a gene with evidence.

When not to use it

Physical binding without direction. Use interactions or intact.
Whole pathway diagrams. Use pathways.

Search on the canvas

Open the node creator and pick Duaer Data → SIGNOR signaling.
Fill Gene (such as TP53). Optional: Organism.
Limit defaults to 10, max 20. Execute.

A search uses 1 credit only when it returns rows. No rows, wrong input, or an upstream failure uses 0.

Call the API

GET https://api.duaer.com/v1/data/signor?gene=TP53&limit=20
Authorization: Bearer <Duaer key>

The call skill below matches Copy skill in the Duaer data market, with parameters, examples, and result fields.

Call skill

Same text as Copy skill.

---
name: duaer-signor
description: >-
  Duaer SIGNOR signaling. Causal signaling relations from SIGNOR: who activates, inhibits, or phosphorylates a protein, with mechanism, modified residue, PubMed evidence, and score.
  One successful search uses 1 Duaer credit.
---

# Duaer SIGNOR signaling

Duaer SIGNOR signaling returns curated causal relations (regulator → effect → target) for a protein from SIGNOR. Duaer resolves a gene symbol to its reviewed UniProt accession first, and orders rows by SIGNOR score.

## When to use

- Explain a pathway step: which kinase phosphorylates a protein, and at which residue.
- List upstream regulators and downstream targets of a gene with evidence.

## When not to use

- Physical binding without direction. Use https://skills.duaer.com/interactions.md or https://skills.duaer.com/intact.md.
- Whole pathway diagrams. Use https://skills.duaer.com/pathways.md.

## Call

`GET https://api.duaer.com/v1/data/signor?gene=TP53&limit=20`

Header: `Authorization: Bearer <Duaer key>`

Use an account key or a model API key.

Get a Duaer key: https://skills.duaer.com/keys.md

## Parameters

Provide `gene`.

- `gene` — Gene symbol or UniProt accession, such as TP53 or P04637.
- `organism` — Optional. human, mouse, or rat. Default human.
- `limit` — Optional. Rows to return, from 1 to 20. Default 10.

## Examples

- `GET https://api.duaer.com/v1/data/signor?gene=TP53&limit=20` — regulators and targets of p53.
- `GET https://api.duaer.com/v1/data/signor?gene=P04637` — the same by UniProt accession.
- `GET https://api.duaer.com/v1/data/signor?gene=Trp53&organism=mouse` — mouse relations.

## Result

The response is `{ "items": [...] }`. Each item has `source`, `title`, `url`, and `summary`, plus:

- `signorId` — SIGNOR relation id.
- `regulator`, `regulatorType`, `regulatorId` — the acting entity.
- `target`, `targetType`, `targetId` — the affected entity.
- `effect`, `mechanism`, `residue` — such as up-regulates activity, phosphorylation, Ser15.
- `pmid`, `evidence` — PubMed id and the curated sentence.
- `score` — SIGNOR confidence from 0 to 1.

Fields without a value are left out.

## Credits

A search that returns at least one row uses 1 credit.
An empty search, a search that finds nothing, or a failed search uses 0.
Wrong input returns 400 with a message and uses 0.
No remaining credits returns 402 and does not search.
A missing key returns 401.

## Related

- https://skills.duaer.com/interactions.md
- https://skills.duaer.com/pathways.md
- https://skills.duaer.com/omnipath.md

Questions

How many credits does a SIGNOR signaling search use in Duaer?

One credit when Duaer returns rows. A search with no rows or an error uses 0.

Why does Duaer SIGNOR look up UniProt first?

SIGNOR finds entities by UniProt accession. Duaer converts a gene symbol to the reviewed accession for the chosen organism.

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