入门
在 Duaer 里查 SIGNOR 信号通路
在 Duaer 里：SIGNOR 因果信号关系：哪些分子激活、抑制或磷酸化某蛋白，含作用机制、修饰位点、PubMed 证据与置信分。一次成功查询用 1 额度。
能拿到什么
Duaer 数据市场里的「SIGNOR 信号通路」：SIGNOR 因果信号关系：哪些分子激活、抑制或磷酸化某蛋白，含作用机制、修饰位点、PubMed 证据与置信分。查到结果时用 1 额度，结果交给数字组织的下一个节点。
从节点创建器选 Duaer 数据 → SIGNOR 信号通路，或打开 数据市场。相关：interactions、pathways、omnipath。
适合做什么
- 解释通路中的一步：哪个激酶在哪个位点磷酸化某蛋白。
- 列出某基因的上游调控者与下游靶标及其证据。
在画布里检索
- 打开节点创建器，选 Duaer 数据 → SIGNOR signaling。
- 填 Gene（基因符号或 UniProt 登录号，如 TP53）；Organism 可选 human、mouse、rat。
- Limit 默认 10，最大 20。执行。
查到结果才扣 1 额度；没有结果、输入有误或上游失败都不扣。
用 API 调用
- GET https://api.duaer.com/v1/data/signor?gene=TP53&limit=20
- Authorization: Bearer <Duaer key>
下方是与数据市场「复制技能」相同的英文技能，含参数、示例与返回字段。
调用技能（英文）
与数据市场「复制技能」一致。
---
name: duaer-signor
description: >-
Duaer SIGNOR signaling. Causal signaling relations from SIGNOR: who activates, inhibits, or phosphorylates a protein, with mechanism, modified residue, PubMed evidence, and score.
One successful search uses 1 Duaer credit.
---
# Duaer SIGNOR signaling
Duaer SIGNOR signaling returns curated causal relations (regulator → effect → target) for a protein from SIGNOR. Duaer resolves a gene symbol to its reviewed UniProt accession first, and orders rows by SIGNOR score.
## When to use
- Explain a pathway step: which kinase phosphorylates a protein, and at which residue.
- List upstream regulators and downstream targets of a gene with evidence.
## When not to use
- Physical binding without direction. Use https://skills.duaer.com/interactions.md or https://skills.duaer.com/intact.md.
- Whole pathway diagrams. Use https://skills.duaer.com/pathways.md.
## Call
`GET https://api.duaer.com/v1/data/signor?gene=TP53&limit=20`
Header: `Authorization: Bearer <Duaer key>`
Use an account key or a model API key.
Get a Duaer key: https://skills.duaer.com/keys.md
## Parameters
Provide `gene`.
- `gene` — Gene symbol or UniProt accession, such as TP53 or P04637.
- `organism` — Optional. human, mouse, or rat. Default human.
- `limit` — Optional. Rows to return, from 1 to 20. Default 10.
## Examples
- `GET https://api.duaer.com/v1/data/signor?gene=TP53&limit=20` — regulators and targets of p53.
- `GET https://api.duaer.com/v1/data/signor?gene=P04637` — the same by UniProt accession.
- `GET https://api.duaer.com/v1/data/signor?gene=Trp53&organism=mouse` — mouse relations.
## Result
The response is `{ "items": [...] }`. Each item has `source`, `title`, `url`, and `summary`, plus:
- `signorId` — SIGNOR relation id.
- `regulator`, `regulatorType`, `regulatorId` — the acting entity.
- `target`, `targetType`, `targetId` — the affected entity.
- `effect`, `mechanism`, `residue` — such as up-regulates activity, phosphorylation, Ser15.
- `pmid`, `evidence` — PubMed id and the curated sentence.
- `score` — SIGNOR confidence from 0 to 1.
Fields without a value are left out.
## Credits
A search that returns at least one row uses 1 credit.
An empty search, a search that finds nothing, or a failed search uses 0.
Wrong input returns 400 with a message and uses 0.
No remaining credits returns 402 and does not search.
A missing key returns 401.
## Related
- https://skills.duaer.com/interactions.md
- https://skills.duaer.com/pathways.md
- https://skills.duaer.com/omnipath.md
常见问题
Duaer 的SIGNOR 信号通路检索扣多少额度？
查到结果时扣 1 额度；没有结果或出错不扣。
为什么 Duaer SIGNOR 要先查 UniProt？
SIGNOR 按 UniProt 登录号查实体；Duaer 会先把基因符号换成所选物种的已审核登录号。
同组