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IMPC mouse phenotypes in Duaer

In Duaer: Significant phenotypes of knockout mice from the International Mouse Phenotyping Consortium: phenotype term, zygosity, sex, p-value, effect size, and test. One successful search uses 1 credit.

What you get

Duaer IMPC mouse phenotypes returns statistically significant genotype–phenotype calls from IMPC, strongest p-values first. It shows what happens in a mouse when a gene is knocked out.

Pick Duaer Data → IMPC mouse phenotypes in the node creator, or open the data market. Related: mgi, mp, phenotypes.

When to use it

Check what a knockout of a gene does in mice before a target study.
Find genes whose knockout causes a phenotype, such as abnormal eye morphology.

When not to use it

Curated mouse gene records and alleles. Use mgi.
Human disease phenotypes. Use phenotypes.

Search on the canvas

Open the node creator and pick Duaer Data → IMPC mouse phenotypes.
Fill Gene (such as Pax6). Optional: Phenotype.
Limit defaults to 10, max 20. Execute.

A search uses 1 credit only when it returns rows. No rows, wrong input, or an upstream failure uses 0.

Call the API

GET https://api.duaer.com/v1/data/impc?gene=Pax6
Authorization: Bearer <Duaer key>

The call skill below matches Copy skill in the Duaer data market, with parameters, examples, and result fields.

Call skill

Same text as Copy skill.

---
name: duaer-impc
description: >-
  Duaer IMPC mouse phenotypes. Significant phenotypes of knockout mice from the International Mouse Phenotyping Consortium: phenotype term, zygosity, sex, p-value, effect size, and test.
  One successful search uses 1 Duaer credit.
---

# Duaer IMPC mouse phenotypes

Duaer IMPC mouse phenotypes returns statistically significant genotype–phenotype calls from IMPC, strongest p-values first. It shows what happens in a mouse when a gene is knocked out.

## When to use

- Check what a knockout of a gene does in mice before a target study.
- Find genes whose knockout causes a phenotype, such as abnormal eye morphology.

## When not to use

- Curated mouse gene records and alleles. Use https://skills.duaer.com/mgi.md.
- Human disease phenotypes. Use https://skills.duaer.com/phenotypes.md.

## Call

`GET https://api.duaer.com/v1/data/impc?gene=Pax6`

Header: `Authorization: Bearer <Duaer key>`

Use an account key or a model API key.

Get a Duaer key: https://skills.duaer.com/keys.md

## Parameters

Provide `gene` or `phenotype`.

- `gene` — Mouse gene symbol, such as Pax6.
- `phenotype` — Optional. Mammalian Phenotype term name, such as abnormal eye morphology.
- `limit` — Optional. Rows to return, from 1 to 20. Default 10.

## Examples

- `GET https://api.duaer.com/v1/data/impc?gene=Pax6` — phenotypes of Pax6 mutants.
- `GET https://api.duaer.com/v1/data/impc?phenotype=abnormal%20eye%20morphology&limit=20` — genes with that phenotype.

## Result

The response is `{ "items": [...] }`. Each item has `source`, `title`, `url`, and `summary`, plus:

- `gene`, `mgiId` — mouse gene symbol and MGI id.
- `phenotype`, `mpId`, `topPhenotype` — Mammalian Phenotype term and its top-level class.
- `zygosity`, `sex`, `lifeStage` — which mice showed it.
- `pValue`, `effectSize` — statistics of the call.
- `allele`, `procedure`, `parameter`, `center` — allele and test details.

Fields without a value are left out.

## Credits

A search that returns at least one row uses 1 credit.
An empty search, a search that finds nothing, or a failed search uses 0.
Wrong input returns 400 with a message and uses 0.
No remaining credits returns 402 and does not search.
A missing key returns 401.

## Related

- https://skills.duaer.com/mgi.md
- https://skills.duaer.com/mp.md
- https://skills.duaer.com/phenotypes.md

Questions

How many credits does a IMPC mouse phenotypes search use in Duaer?

One credit when Duaer returns rows. A search with no rows or an error uses 0.

Does Duaer IMPC accept human gene symbols?

Use the mouse symbol, such as Pax6 or Trp53. Mouse symbols usually match the human one with only the first letter capitalized.

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